Enhancement of leukocyte adhesion after percutaneous irradiation in rats with hepatocellular carcinoma

摘要

AIM: To evaluate the effects of percutaneous radiation on leukocyte-endothelium interaction (LEI) in experimental hepatocellular carcinoma (HCC).METHODS: Twelve ACI rats underwent HCC-inoculation,six of which on day 12 received low-dose external radiation and six did not. After 12 h intravital microscopy was performed.RESULTS: LEI was significantly reduced in tumor tissue.However, irradiation of liver sinusoids and tumor tissue with 6 Gy led to a significant activation of leukocyte adhesion in the tumor with a marked increase of the proinfiammatory cytokine TNF-α.CONCLUSION: The findings indicate that the immunological tumor-endothelial barrier can be overcome by external irradiation.