患多囊卵巢综合征的中国妇女过氧化物酶体增殖物激活受体γ和共活化物1α基因的多态性

摘要

The polymorphisms of the peroxisome proliferator-activated receptor- γ (Pro12Ala) and its coactivator- 1 (Gly482- Ser) genes were investigated among 201 Chinese Han women with polycystic ovary syndrome (PCOS) and among 147 regularly cycling women as control subjects. We did not find statistically significant differences with peroxisome proliferator-activated receptor- γ 2 Pro12Ala and peroxisome proliferator- activated receptor-gamma- 1α Gly482- Ser polymorphism distributions between Chinese women with PCOS and controls, or with body mass index and reproductive hormones among various genotypic groups of PCOS, suggesting that these genetic mutants did not have an effect on the susceptibility to PCOS.