补肺活血中药对间质性肺病合并肺部感染患者肺功能的影响

摘要

Objective:To investigate the clinical efficacy of Chinese traditional herbs for interstitial lung disease (ILD)patients with pulmonary infection.Methods:Eighty one patients were randomly divided into two groups.The 41 patients in treatment group were ap-plied with the western standard regimen plus Chinese traditional herbs that could invigorate lung and activate blood.The other 40 patients in control group were treated with standard western regimen alone.By observing changes in lung function,artery blood,gas tension and hospitalization days,the efficacy of two therapeutic measures were evaluated.Results:After treatment,significant improvements of partial pressure of oxygen in arterial blood (PaO2 ),total lung capacity,carbon monoxide diffusing capacity were found in both groups (P<0.05),while patients in treatment group achieved a mean total lung capacity of (70.44 ±8.07)% (vs.control group,P=0.012),car-bon monoxide diffusion rate of (69.56 ±11.96)% (vs.control group,P=0.025)and hospitalization days of (10.93 ±2.38)days (vs.control group,P=0.017).The PaO2 was (75.41 ±7.47)mmHg in treatment group which was significantly improved compared to (72.23 ±5.36)mmHg in control group (P=0.030).Conclusion:TCMherbs that can invigorate lung and activate blood can improve the lung diffusing capacity and hypoxic condition,as well as shorten the hospitalization days in ILD patients with pulmonary infection.%目的：探讨补肺活血中药治疗间质性肺病（ILD）合并肺部感染患者的临床疗效。方法：将81例间质性肺病合并肺部感染患者随机分为2组。治疗组41例，采用补肺活血中药加味及常规西医治疗；对照组40例，单纯采用常规西医治疗。通过观察患者肺功能变化来评价临床疗效，同时比较2组的住院天数。结果：治疗后，2组患者的动脉血氧分压、肺总量、一氧化碳弥散率时间效应均比治疗前有明显改善（P ＜0.05）。治疗组的肺总量为（70.44±8.07）％，一氧化碳弥散率为（69.56±11.96）％，平均住院天数为（10.93±2.38）d，均优于对照组（P＜0.05）。此外，治疗组的缺氧状态也得到更好的改善，动脉血氧分压为（75.41±7.47）mmHg，相比对照组的（72.23±5.36）mmHg有显著提高（P＝0.030）。结论：补肺活血中药可以明显改善间质性肺疾病合并肺部感染患者的肺弥散功能，纠正缺氧状态，缩短住院时间。