中药细胞级粉碎技术在中药巴布剂中的应用分析

摘要

Objective:To explore the value of cellular level pulverizing technology used in cataplasm.Methods:Common fine and ultra-fine powder poultice were prepared,and the different sizes of cataplasma puhuang psorhamnetin-3-O-neohesperidin transdermal absorp-tion were comparatively analyzed.Results:The permeation rate of isorhamnetin-3-O-neohesperidin in ultrafine powder cataplasma was significantly higher than that in ordinary poultice (P<0.05 ).Conclusion:Cellular level pulverizing technology used in Chinese medi-cine preparations can help to improve the quality and bioavailability of drugs,optimize the production processes of Chinese medicine preparations and reduce drugs profligacy,and hence it deserves further application.%目的：研究中药细胞级粉碎技术应用于中药巴布剂的价值。方法：制备普通细粉巴布剂和超细粉巴布剂，比较分析不同粒径巴布剂中蒲黄异鼠李素-3-O-新橙皮苷透皮吸收性。结果：超细粉巴布剂中异鼠李素-3-O-新橙皮苷的渗透速率显著高于普通巴布剂（P＜0.05）。结论：中药细胞级粉碎技术应用于中药药剂的制备，有利于提高药物的质量以及生物利用度，优化中药药剂生产流程，降低药物浪费，值得进一步推广应用。