金天格胶囊治疗乳腺癌患者芳香化酶抑制剂相关的肌肉关节症状的研究

摘要

Objective:To observe the effect of Jintiange capsule in relieving muscle and joint discomfort induced by Aromatase In-hibitor(AI)in patients with breast cancer.Methods:To select 50 cases of patients with breast cancer,who had developed dis-comfort in muscle or joint after taking AI.In a successive of twelve weeks,Jintiange capsules were given to them tree times a day, 1.2g for each time.The statistics of BPI,VAS,FACT-B,Serum E2 and FSH were taken before,during and after the capsules taken,and were then compared and analyzed by the conductors.Results:Jin Tiange capsule can effectively alleviate the patientsaverage pain,pain interference,worst pain and joint stiffness.In addition,it has no obvious improvement except for pain in FACT-B.At the same time,there is no change in patientsSerum E2 and FSH level.Conclusion:Jintiange capsule can effectively alleviate muscle and joint pain due to AI.%目的：研究金天格胶囊治疗芳香化酶抑制剂相关的肌肉关节症状的有效性。方法：采用单臂开放的研究方法，挑选50例服用 AI，并且产生或加重相关肌肉关节症状的乳腺癌患者。使其服用金天格胶囊12周（1.2 g／次，3次／d），同时在服用前、中、后进行 BPI、VAS、FACT-B、血清 E2及 FSH 的记录，并筛选有价值的指标进行分析和评价。结果：金天格胶囊能够有效地缓解患者的平均疼痛，最剧疼痛，疼痛干扰和晨僵。对 FACT-B 中除疼痛之外的其他方面没有明显的改善。同时，不影响患者血清 E2、FSH 水平。结论：金天格胶囊能有效的缓解芳香化酶抑制剂相关的肌肉关节症状。