川芎清脑颗粒治疗偏头痛(风湿蒙蔽,瘀血阻滞证)的临床观察

摘要

Objective:To observe the therapeutic effect and safety of Chuanxiong Qingnao Granules in the treatment of migraine with wind wetness and blood stasis syndrome.Methods:A total of 496 patients diagnosed with migraine with wind wetness and blood stasis syndrome were included in this research by the method of observational study.A multicenter,large sample,observational study was conducted for 2 weeks to observe the improvement rate of headache onset,onset time,headache attack and so on.Results:after two weeks' treatment,the 481 patients of migraine treated with Chuanxiong Qingnao Granules had no obvious change in headache frequency,but degree of headache (VAS score) and headache days became lower than before treatment,and the differences were statistically significant (P ＜ 0.05);Follow-up duration patients with 4 years or less showed that the non-onset percent of the patents who had the disease more than four years' patients was ＞ 70％ after stopping treatment for two weeks.Drugs' accumulated effective rate was 54.1％ after five day's treatment;The period of evaluation,drug average effective time was 2.36 hours;And the amount of patients who took painkillers were significantly reduced,and the difference was statistically significant (P ＜ 0.05).Conclusion:Chuanxiong Qingnao Granules can significantly reduce the symptom of headache,it also takes less time to become effective,and it has no obvious adverse reaction and good safety,which is worth of popularization in clinical practice.%目的:观察川芎清脑颗粒治疗偏头痛(风湿蒙蔽,瘀血阻滞证)临床疗效特点及安全性.方法:选择偏头痛经中医辨证为风湿蒙蔽,瘀血阻滞证患者496例,采用多中心,大样本,观察性研究方法,疗程为2周.观察头痛发作次数,起效时间,头痛发作程度等方面的改善率.结果:481例偏头痛患者经过川芎清脑颗粒治疗2周后,头痛发作次数未见明显变化,但头痛发作程度(VAS评分)及头痛发作天数均低于治疗前水平,且差异有统计学意义(P＜0.05);病程≤4年的患者,停药2个月后无头痛发作累积百分比＞70％;患者服药第5天,药物累积起效率为54.1％;评价期内,药物平均起效时间为2.36 h;且患者服用止痛药暴露程度明显减少,且差异有统计学意义(P＜0.05).结论:川芎清脑颗粒可显著减轻患者头痛发作程度,具有起效时间短的特点,且无明显不良反应,安全性好,值得在临床中推广.