多毛症与非多毛症多囊卵巢综合征妇女基线特征与临床结局

摘要

Objective:To investigate the differences in baseline characteristics and treatment outcomes between hirsutism and non -hirsutism polycystic ovary syndrome patients ,and to provide a theoretical basis for the syndrome characteristics and diagnosis and treatment of polycystic ovary syndrome.Methods:This study was a secondary analysis based on a multicenter ,randomized,double-blind,placebo-controlled infertility clinical trial.According to the Rotterdam diagnostic criteria ,644 women with infertility polycys-tic ovary syndrome were included in 19 sub-centers between November 2009 and February 2013.Subjects were divided into hirsut-ism group (HI group,≥5 points) and non-hirsutism group (Non-HI group,＜5 points) according to the Ferriman-Gallwey scoring criteria.The differences in baseline characteristics and clinical outcomes between the two groups were compared .Results:1.Base-line characteristics:waist circumference,diastolic blood pressure,heart rate,LH and LH/FSH levels were significantly lower in the HI group than in the Non-HI group (P＜0.05),while the proportion of the acne score and the bilateral ovary "necropic sign" was higher than Non-HI group (P＜0.05); 2.Clinical outcomes:The pregnancy rate of subjects in HI group was significantly lower than that in Non-HI group (P＝0.04).Conclusion:The hirsutism and non-hirsutism polycystic ovary syndrome subjects have dif-ferent clinical phenotypic characteristics.The hirsutism polycystic ovary syndrome subjects have the characteristics of low concep-tion rate.%目的:探讨多毛症和非多毛症多囊卵巢综合征受试者基线特征及治疗结局的差异,旨在为多囊卵巢综合征的表型特征及诊治提供理论依据.方法:选取本研究是一项基于多中心、随机、双盲、安慰剂对照不孕症临床试验的二次分析.根据鹿特丹诊断标准,在国内2009年11月至2013年2月间19家分中心纳入的不孕症多囊卵巢综合征女性644例进行研究.依据Ferriman-Gallwey评分标准,将受试者分为多毛症组(HI组,≥5分)和非多毛症组( Non-HI组,＜5分),比较2组基线特征及临床结局的差异.结果:1)基线特征:HI组腰围、舒张压、心率、LH以及LH/FSH水平均显著低于Non-HI组(P＜0.05),而痤疮评分以及双侧卵巢"项链征"形态的比例均高于Non-HI组(P＜0.05);2)临床结局:HI组受试者受孕率显著低于Non-HI组(P＝0.04).结论:多毛症与非多毛症多囊卵巢综合征受试者具有不同的临床表型特征,多毛症多囊卵巢综合征受试者具有低受孕率的特点.