为提高钛氧膜表面官能团密度，改善其血液相容性，特在其表面原位构建多羟基树状分子。本文通过合成11-羟基十一烷基膦酸（HUPA）后在钛氧膜表面进行自组装，通过依次重复利用传统的亲核取代反应等，制备三代端羟基树状表面。选用红外（FTIR）对HUPA的合成进行定性表征，利用扫描电子显微镜（SEM）进一步观察材料表面形貌并检测制备于氧化钛薄膜端羟基树状表面润湿性的改变，通过血小板粘附实验考量改性后钛氧膜的抗血小板粘附与激活的能力。采用纤维蛋白原粘附实验进一步测试改性材料的血液相容性。实验结果表明端羟基树状表面的制备有效改善了氧化钛薄膜的抗凝血性能，同时提高了材料表面的官能团数量，为后续的组装改性提供了条件。%In order to improve the surface functional group density of titanium oxide film, improve the blood compatibility, it builds the polyhydroxy dendrimer in situ. Through the synthesis of 11-hydroxy-undecyl acid (HUPA), this paper conducted self-assembly in situ on titanium oxide film and prepared the three generations of terminal hydroxyl dendritic surface by sequentially recycling conventional nucleophilic substitution reaction. It selected infrared(FTIR)to characterize the synthesis of HUPA, used the scanning electron microscope (SEM) for the further observation of surface topography and detection of the change of hydroxy tree surface wettability prepared in the titanium oxide film, and examined the ability of anti-platelet adhesion and activation of the modified titanium oxide film. The fibrinogen adhesion assay was used to further test the blood compatibility of modified material. Experimental results show that the preparation of hydroxyl-terminated dendritic surface can effectively improve the anticoagulant properties of titanium oxide films, while increase the amount of surface functional groups, and provide the conditions for subsequent assembly modification.
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