环形RNAs形成机制的多样性

摘要

环形RNAs是一种结构与常见线性RNA不同的一种环形转录物.生命的各个领域环形RNAs广泛存在,包括真核生物、细菌、古生菌和病毒,而且在神经细胞中高度表达,说明它们可能具有一定的生物功能.多年来,我们对于它们的形成机制和功能并不清楚.最近的研究表明环形RNAs的形成机制和功能具有多样性,例如有外显子环化、内含子环化、细菌基因组环化等.%Circular RNAs is a ring transcript with a structure different from the common linear RNA.In all areas of life,ring RNAs is widespread,including eukaryotes,bacteria,archaea,and viruses,and is highly expressed in nerve cells,suggesting that they may have certain biological functions.Over the years,we have not been clear about their formation mechanisms and functions.Recent studies have shown that the formation mechanism and function of circular RNAs are diverse,such as exon cyclization,intron cyclization,and bacterial genome cyclization,etc.