Evaluating the clinical efficacy of Thunder-Fire moxibustion combined with ovulation monitoring in the treatment of adenomyosis combined with infertility

摘要

目的:评价雷火灸联合排卵监测治疗子宫腺肌病合并不孕的临床疗效.方法:选择诊断符合子宫腺肌病合并不孕且中医辨证属于寒凝血瘀(具有经前综合症或经期下腹冷痛,得热痛减,肢端冰冷等临床表现)的患者120例,随机分为治疗组和对照组,每组各60例.治疗组予雷火灸联合排卵监测,对照组单纯予排卵监测,比较两组6个月经周期内的妊娠率,痛经和中医证候群的改善情况以及血清癌抗原125的水平.结果:治疗组6个月经周期内妊娠率与对照组相比有统计学意义(50.0％vs 23.3％,P=0.021).与对照组相比,治疗组痛经与中医证候群改善明显(分别为3.87±2.03 vs.5.70±1.01,P=0.002 and 7.33±4.11 vs.10.52±2.33,P=0.006).两组相比血清癌抗原125的水平有显著性差异(55.45±14.65 vs 63.34±11.41,P=0.031).但是子宫平均直径与对照组相比差异无统计学意义(67.13±7.59 vs.69.89±5.30,P=0.137).结论:雷火灸联合排卵监测能有效地提高子宫腺肌症不孕患者的受孕率.%This study evaluated the clinical efficacy of Thunder-Fire moxibustion combined with ovulation monitoring for the treatment of adenomyosis-associated infertility. A series of 120 patients diagnosed with uterine adenomyosis and infertility and cold coagulation blood stasis syndrome in traditional Chinese medicine (with the clinical manifestations of premenstrual or menstrual lower abdomen cold pain, pain reduction with heat application, and cold extremities) were randomized equally to treatment group with Thunder-Fire moxibustion and ovulation monitoring as well as control group with ovulation monitoring only. Treatment continued for six menstrual cycles. The pregnancy rate of the treatment group was significantly increased with the control group (50.0％ vs. 23.3％, P = 0.021). Dysmenorrhea and the traditional Chinese medicine syndrome in the treatment group improved significantly compared with the control group (3.87 ± 2.03 vs. 5.70 ± 1.01, P =0.002 and 7.33 ± 4.11 vs. 10.52 ± 2.33, P = 0.006, respectively), and there was also significant between-group differences in serum cancer antigen 125 (55.45 ± 14.65 vs. 63.34 ± 11.41, P = 0.031). However, the average uterus diameters in the treatment and control groups were not significantly different (67.13 ± 7.59 vs. 69.89 ± 5.30, P = 0.137). Thunder-Fire moxibustion with ovulation monitoring improved the pregnancy rate of patients diagnosed with adenomyosis-associated infertility.