不同乙醇摄入量对心脏结构、功能及氧化应激的影响

摘要

Objective:To explore the effects of different amounts of ethyl alcohol intake on cardiac structure and function, and the effects of oxidative stress on cardiac muscle injury caused by ethyl alcohol. Methods: Two hundred and ninety-three subjects were divided into 4 groups according to the different amounts of ethyl alcohol intake including small amounts of alcohol group(5-20 g/d), the median amounts of alcohol group (20-80 g/d), large amounts of alcohol group(≥80 g) and non-alcohol group (<5 g/d). The echocardiogram test was performed in subjects. The levels of blood B urine sodium pep-tide (BNP), superoxide dismutase(SOD)and metal sulfur protein (MT) were also detected. Results: The left ventricular end systolic diameter (LVSD), the left ventricular end diastolic diameter (LVDD) and the level of serum BNP increased, but the left ventricular ejection fraction (LVEF), the left ventricular fractional shortening (FS) and E/A ratio decreased in median and large amounts of alcohol groups than those of non-alcohol group. The values of LVSD and LVDD increased, but LVSD and LVDD decreased in large amounts of alcohol group than those of median amounts of alcohol group. There was a higher serum level of MDA in median and large amounts of alcohol groups compared with that of non-alcohol group and small amounts of alcohol group. There were significantly lower serum levels of SOD and MT in median and large amounts of alcohol groups than those in small amounts of alcohol group and non-alcohol group (P < 0.0S). Conclusion: Median and large amounts of alcohol intake induced cardiac dilatation and heart dysfunction. There was no influence on cardiac structure and function with small amounts of alcohol intake. The large and median amounts of alcohol intake activate oxidation stress, while small amounts of alcohol intake reduce the level of oxidation stress.%探讨不同乙醇摄入量对心脏结构和功能的影响及氧化应激在乙醇所致心肌损伤中的作用.方法:对293例调查对象按照平均每天摄入乙醇量的不同,分为小量饮酒组(5～20g/d)、中量饮酒组(20～80g/d)、大量饮酒组(≥80g/d)和不饮酒组(＜5 g/d).各组均行超声心动图检查和测定血B型尿钠肽(BNP),同时测定血清中丙二醛(MDA)、超氧化物歧化酶(SOD)、金属硫蛋白(MT)等氧化应激指标.结果:中、大量饮酒组与不饮酒组比较,左室收缩末期内径(LVSD)、左室舒张末期内径(LVDD)增高,血清BNP水平升高,而左室射血分数(LVEF)、左室短轴缩短率(FS)和E/A比值降低；大量饮酒组较中量饮酒组LVSD、LVDD增高,而LVEF和FS降低.血清MDA在中、大量饮酒组高于不饮酒组和小量饮酒组,血清SOD和MT在中、大量饮酒组水平低于不饮洒组和小量饮酒组,差异有统计学意义(P＜0.05).结论:中、大量饮酒在一定程度上使心室扩张,心功能下降,而小量饮酒未对心脏结构和心功能产生影响.中、大量饮酒者机体氧化应激状态活跃,而小量饮酒可使机体氧化应激水平下降.