树突状细胞（DCs）是体内作用最强的抗原提呈细胞，具有双向免疫调节功能，既可诱导免疫应答，又可诱导免疫耐受。调节性树突状细胞（DCreg）具有负向免疫调节功能，可降低T细胞的免疫活性，诱导免疫耐受。DCreg可通过不同机制经药物、细胞因子、局部微环境产生，其诱导的免疫耐受作用在器官移植、自身免疫性疾病中具有重要的临床意义。近期，DCreg的耐受性和安全性已在1型糖尿病和类风湿关节炎的临床试验中得到证实。本文就DCreg的获取途径及其诱导免疫耐受的临床应用综述如下。%Dendritic cells (DCs) are potent antigen presenting cells with dual functions in immune response or im-mune tolerance. Regulatory dendritic cells (DCreg) have negative immunomodulation effects. They can inhibit T cell stimula-tory activity and induce immune tolerance. DCreg can be generated by the induction of drugs, cytokines and cell microenvi-ronment with different mechanisms. DCreg induced tolerance is of great clinical significance in organ transplantation and au-toimmune disease. Recently, several clinical trials have been conducted in type 1 diabetes and rheumatoid arthritis, with re-sults that emphasize the tolerance and safety of DCreg therapy. In this review, we will focus on the strategies for generating DCreg and the clinical application of immune tolerance.
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