首页> 中文期刊> 《肿瘤学与转化医学(英文)》 >小剂量周方案单药司莫司汀治疗伴有广泛皮下转移的MGMT甲基化阳性的非特异性外周T细胞淋巴瘤1例报道(英文)

小剂量周方案单药司莫司汀治疗伴有广泛皮下转移的MGMT甲基化阳性的非特异性外周T细胞淋巴瘤1例报道(英文)

         

摘要

Peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS) is a heterogeneous group of aggressive T-cell lymphomas with no treatment consensus and poor prognosis. We herein described an extraordinary refractory case of PTCL-NOS with widely involvement of subcutaneous tissue, which showed an excellent response to Semustine personal- ized chemotherapy based on the detection finding of positive O 6 -methylguanine-DNA methyltransferase (MGMT) promoter methylation. This is the first english report to indicate that single nitrosourea agent such as Semustine may have good efficacy and safety for widespread subcutaneous involvement of PTCL-NOS with positive MGMT promoter methylation.

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