We presented a case of giant neurofibromas arising from the jejunal mesentery of a 52-year-old man. The patient presented with epigastric fullness,and decrease of food intake,but without stigmata of neurofibromatosis-1. Ultrasonography,computed tomography (CT) and MR imaging revealed two large masses in the abdomen extending to the pelvis. Total resection of the tumors together with corresponding segments of intestines was performed. Histological examination and immunocytochemistry for S-100 protein confirmed the masses to be multiple neurofibromas of the mesentery. We also discussed the clinical features,and treatment approaches of similar cases in literatures.
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