目的：探讨硬膜外麻醉与全麻对下肢骨关节手术患者围术期凝血功能的影响。方法2012年5月至2013年5月期间,我院诊治的60例下肢骨关节手术患者,随机将其分为对照组(全麻)和观察组(硬膜外麻醉),对两组麻醉前(T0)、麻醉后6h(T1)、术后24h(T2),对两组凝血酶原时间(PT)、活化部分凝血酶原时间(APTT)、凝血酶时间(TT)、纤维蛋白原( Fbg)等凝血功能指标,以及围术期血栓性并发症( DVT)发生率,进行检测和比较。结果与T0相比,在T1、T2时间点,两组PT、TT时间明显延长,而观察组APTT时间明显延长, P<0．05；与对照组相比,观察组DVT发生率显著降低,P<0．05。结论对于下肢骨关节手术患者,硬膜外麻醉能够有效降低围术期血栓性并发症的发生率,具有更高的安全性。%Objective To study the effect of coagulation function of epidural anesthesia and general anesthesia on patients with lower limb joint operation during perioperative period. Methods The 60 patients with lower limb joint operation in our hospi-tal during the period rom May 2012 to May 2013 were randomized into the control group ( general anesthesia) and the observation group (epidural anesthesia). The coagulation function parameters such as prothrombin time (PT), activated partial thromboplas-tin time ( APTT) , thrombin time ( TT) and fibrinogen ( Fbg) and the incidence of DVT in the two groups were detected and com-pared. Results compared with the T0 time point, the PT and TT at time points of T1 and T2 in the two groups were significantly increased, the APTT at time points of T1 and T2 in the observation group was obviously increased, P<0. 05;compared with the control group, the incidence of DVT in the observation group was significantly decreased, P<0. 05. Conclusion For the patients with lower limb joint operation, the epidural anesthesia can effectively reduce the incidence of DVT and has the higher safety.
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