薰衣草精油对血管性痴呆大鼠认知功能的影响

摘要

目的探讨薰衣草精油对血管性痴呆大鼠认知功能的影响。方法采用缺血再灌注大鼠血管性痴呆( vas-cular dementia, VD)模型为研究对象,VD大鼠分为假手术、VD模型组、薰衣草精油30mg/kg组、薰衣草精油100mg/kg组和脑复康100mg/kg组。以定位航行实验和空间探索实验对大鼠进行对比研究,考察VD大鼠海马组织Ach、SOD、MDA等观察指标的变化。结果①薰衣草精油能缩短VD大鼠定位航行时间,模型组和假手术组间差异有统计学意义( P<0.01)；②薰衣草精油能减少VD大鼠空间探索实验目标象限停留时间和穿越虚拟平台次数(P<0.01)；③薰衣草精油能增加VD大鼠海马组织Ach水平,上调SOD水平和下调MDA水平(P<0.01)。结论①薰衣草精油能够改善VD大鼠海马组织氧化应激状态；②薰衣草精油能够改善VD大鼠认知功能。%Objective To study the effects of lavender essential oil on cognitive function of rats with vascular dementi-a.Methods All rats were divided into sham operation group and intervention group, the intervention group was also divided into VD model group and lavender essential oil 30mg/kg group;100mg/kg group, and piracetam 100mg/kg group.These were compara-tive studied by positioning navigation experiments and space exploration experiments,by detected and analyzed with VD rats Hippo-campus Ach, SOD and MDA.Results ①Lavender essential oil can shorten the navigation time of VD rats, the difference be-tween model group and control group was statistically significant ( P<0.01 ). ②Lavender essential oil can reduce the time and times in which VD rats explored experimental target and throughed the virtual platform times(P<0.01).③Lavender essential oil increased the level of Ach VD in hippocampus of rats, increased the level of SOD and lowered the level of MDA ( P <0.01 ) . Conclusion ①Lavender essential oil could reduce oxidative stress in VD rats hippocampus;②Lavender essential oil could im-prove VD rats cognitive function.