目的：探讨C35蛋白在乳腺癌中的表达及与Her2表达的相关性。方法应用免疫组化Envision 二步法,检测58例乳腺癌组织和12例正常乳腺组织中C35和Her2的表达情况,并结合其临床病理特点进行分析。结果乳腺癌组织中C35蛋白的表达阳性率为62．07%(36/58),显著高于正常乳腺组织,差异有统计学意义(P<0．05),在正常乳腺组织C35蛋白不表达。 C35蛋白表达与乳腺癌组织临床病理学特点存在相关性,随着乳腺癌组织的临床TNM分期、病理组织学分级的增加,C35蛋白阳性率显著升高,差异有统计学意义(P<0．05)；乳腺癌组织C35蛋白表达与Her2蛋白的表达呈正相关(rs=0．348)。结论 C35参与乳腺癌的生长、侵袭和转移过程,可作为乳腺癌诊治的新靶点。%Objective To investigate the expression of C35 in human breast carcinoma and study the relationship between C35 and Her2. Methods The Envision immunohistochemical stain method was used to detectC35 and Her2 protein expressions in 58 samples of breast carcinoma tissues and 12 cases of normal breast tissues. And clinical data were analyzed retrospectively. Re-sults Positive rate of C35 was 62. 07%(36/58),and none of normal breast tissues was stained. The expression of C35 in human breast carcinoma was significantly higher than that in normal breast tissues(P<0. 05),and the C35 protein in normal breast tis-sues showed no expression. The expression of C35 related dosely to clinical chara cteristics of breast cancer. The increased positive level of C35 was associated with advanled TNM stage and his tological grtade. There was a stable positive correlation between C35 and HER2(rs=0. 348). Conclusion C35 participate the development,invasion and metastasis process of breast carcinoma. And can be used as a marker in diagnosis and a new target of in treatment of breast carcinoma.
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