重复经颅磁刺激治疗精神分裂症顽固性幻听的效果及作用机制分析

摘要

Objective To investigate the effect and mechanism of repetitive transcranial magnetic stimulation( rTMS) in the treatment of intractable auditory hallucinations in schizophrenia. Methods From February 2016 to November 2017,126 pa-tients with intractable hearing hallucinations of schizophrenia treated in our hospital were selected and randomly divided into two groups. Patients in the control group were treated with pseudo stimulation,while the patients in the trial group were given rTMS. The differences of AHRS,CGI,PSYRATS,SAS and PANSS between the two groups were observed and compared. Results After treat-ment,the AHRS score of the patients in the trial group was(4. 51 ± 1. 25),and the CGI score was(4. 07 ± 1. 32),significantly lower than those in the control group(P＜0. 05);In the test group,the PSYRATS score was(14. 64 ± 2. 15),and the SAS score was(30. 86 ± 4. 07),significantly lower than those in the control group(P＜0. 05);After treatment,the scores of auditory halluci-nations,positive symptoms,negative symptoms and the general condition analysis were(2. 93 ± 0. 97),(16. 93 ± 3. 62),(12. 99 ± 3. 58)and(23. 01 ± 3. 53) respectively in the experimental group,which were significantly improved compared with the control group(P＜0. 05). Conclusion rTMS therapy can relieve the symptoms of schizophrenia,improve the symptoms of auditory hallu-cinations and relieve the bad emotions,which is worth popularizing.%目的 探讨重复经颅磁刺激(rTMS)治疗精神分裂症顽固性幻听的效果及作用机制.方法 选取2016年2月至2017年11月在我院治疗的126例精神分裂症顽固性幻听患者随机分组,对照组患者应用伪刺激治疗,试验组患者给予rTMS,观察比较两组AHRS、CGI、PSYRATS、SAS和PANSS差异.结果 治疗后试验组患者AHRS(4. 51 ± 1. 25)分、CGI(4. 07 ± 1. 32)分较对照组明显下降,差异有统计学意义(P＜0. 05);试验组PSYRATS(14. 64 ± 2. 15)分、SAS(30. 86 ± 4. 07)分明显低于对照组,差异有统计学意义(P＜0. 05);治疗后试验组患者幻听(2. 93 ± 0. 97)分、阳性症状评分(16. 93 ± 3. 62)分、阴性症状评分(12. 99 ± 3. 58)分、一般情况分析(23. 01 ± 3. 53)分同对照组比较明显改善,差异有统计学意义(P＜0. 05).结论 针对精神分裂症顽固性幻听患者采用rTMS治疗可缓解精神分裂症状,改善幻听症状,缓解不良情绪,值得推广应用.