Dolutegravir plus lamivudine versus dolutegravir plus tenofovir disoproxil fumarate and emtricitabine in antiretroviral-naive adults with HIV-1 infection(GEMINI-1 and GEMINI-2):week 48 results from two multicentre,double-blind,randomised,non-inferiority,phase 3 trials

摘要

Background:Effective two-drug regimens could decrease long-term drug exposure and toxicity with HIV-1 antiretroviral therapy(ART).We therefore aimed to evaluate the efficacy and safety of a two-drug regimen compared with a three-drug regimen for the treatment of HIV-1 infection in ART-naive adults.