目的：评价阴道镜下活体组织检查联合人乳头瘤病毒（HPV）检测预测宫颈癌及癌前病变的临床价值。方法：选择2013年8月-2014年11月在我院宫颈门诊行宫颈液基薄层细胞学（TCT）检测结果异常（非典型鳞状上皮细胞及以上）者289例，随机分为HPV组（行HPV检测，n=103）、阴道镜组（行阴道镜检查，n=94）、联合组（行HPV检测和阴道镜检查，n=92）。所有患者均行宫颈病理检测，比较3种检测方法在预测宫颈癌及癌前病变的价值。结果：3种方法检测阳性率分别为57.28%、59.57%和72.83%（F=4.824, P＜0.05），而病理组织学检测结果阳性率分别为55.93%、55.36%和77.61%（F=5.147, P＜0.05）。结论：阴道镜下活体组织检查联合人乳头瘤病毒检测可显著提高宫颈癌及癌前病变的检出率和预测效能，具有较高的临床应用价值。%Objective: To discuss the clinical value of the examination of biopsy under colposcopy combined with the detection of human papilloma virus (HPV) for the prediction of cervical cancer and precancerous lesions.Methods: Two hundred and eighty-nine cases of patients with atypical squamous cells performing a detection of thinprep cervical cytology (TCT) from August, 2013 to November, 2014 at the department of gynecology in our hospital were selected and randomly divided into a HPV group (underwent HPV test,n=103), a colposcopy group (underwent colposcopy,n=94), a combinational group (underwent both,n=92). All patients underwent the detection of cervical pathology and the diagnostic value of three methods were compared. Results: The positive rates in three groups were 57.28%, 59.57% and 72.83%, respectively (F=4.824,P<0.05), while the positive rates of the detection of cervical pathology were 55.93%, 55.36% and 77.61%, respectively (F=5.147,P<0.05).Conclusion:Colposcopy combined with HPV detection can signiifcantly improve the diagnostic efifcacy of cervical cancer and precancerous lesions with a higher value of clinical application.
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