卵巢上皮性癌组织中β-catenin、E-cadherin表达变化及意义

摘要

Objective To investigate the expression of β-catenin, E-cadherin in epithelial ovarian cancer and to explore their clinical significance.Methods Expressions of β-catenin, E-cadherin was detected with immunohistochemistry assay in 49 specimens of epithelial ovarian cancer, 10 borderline epithelial ovarian tumors, 16 benign epithelial ovarian tumors.Results The abnormal expression of β-catenin and E-cadherin were significantly higher in the ovarian cancer (79.59％ and 67.35％) than in the borderline (30.00％ and 20.00％) and benign (25％ and 0) ovarian epithelial tumors( P ＜ 0.01 ).By comparing with the abnormal expression of β-catenin and E-cadherin in the borderline and benign ovarian epithelial tumors,P ＞ 0.05.The expression pattern ofβ-catenin was associated with histological subtypes, differentiation stages and peritoneal metastasis ( P ＜ 0.05 ).The expression pattern of E-cadherin was associated with histological subtypes, FIGO stages , peritoneal metastasis, and residual size ( P ＜ 0.05 ).The expression of beta-catenin and E-cadherin was positively correlated ( r = 0.525 8, p ＜ 0.05 ) in spccimens of ovarian cancer.Conclusions Down-regulation of βcatenin and E-cadherin in specimens of ovarian cancer.They have important effects on pathogenesis and development of ovarian epithelial tumors.%目的 观察卵巢上皮性癌(卵巢癌)组织中β-catenin、E-cadherin的表达变化,并探讨其意义.方法 采用免疫组化SABC法检测49例上皮性卵巢癌、10例交界性囊腺瘤及16例良性卵巢肿瘤患者肿瘤组织中的β-catenin、E-cadherin.结果 卵巢癌组织中β-catenin、E-cadherin的异常表达率分别为79.59%(39/49)、67.35%(33/49),明显高于良性卵巢肿瘤组织的25%(4/16)、0和交界性卵巢囊腺瘤组织的30.00%(3/10)、20.00%(2/10),P均＜0.01.良性卵巢肿瘤与卵巢交界性囊腺瘤组织中β-catenin、E-cadherin的异常表达率相比P均＞0.05.β-catenin与卵巢癌病理类型、病理分级和腹腔转移有关(P均＜0.05).E-cadherin与卵巢癌病理类型、临床分期、腹腔转移和术后有无残余瘤有关(P均＜0.05).卵巢癌组织中的β-catenin、E-cadherin的异常表达呈正相关(r＝0.525 8,P＜0.05).结论 卵巢癌组织中β-catenin、E-cadherin表达下调.二者在卵巢肿瘤发生、发展过程中起重要作用.