Objective To investigate whether cardiac troponin T (cTnT) independently predicts outcome in chronic peritoneal dialysis (PD) with end-stage renal disease. Methods Baseline cTnT, echocardiography and biochemical characteristics were assessed in 214 chronic PD patients who were followed prospectively for 3 years or until death. Results Increased cTnT correlated significantly with history of diabetes and cardiovascular events (CVE) , increase of high-sensitivity CRP and left ventricular mass index (LVMI) , decrease of eGFR and left ventricular ejection fraction. Kaplan-Meier survival curve analysis revealed cTnT≥0.1 μg/L was linked to fatal and nonfatal CVE, all-cause mortality and cardiovascular death. Multivariable COX regression analysis indicated cTnT was independently predictive of fatal and nonfatal CVEs, all-cause mortality, cardiovascular death. Conclusion cTnT is an independent predictor of long term mortality, cardiovascular death and events in PD patients.%目的 探讨腹膜透析患者血清心肌肌钙蛋白T(cTnT)对其心脑血管疾病及死亡的预测价值.方法 选择衡阳市第一人民医院行规律腹膜透析患者214例,检测透析前后生化及心脏形态改变.随访3a或至其死亡,记录随访期间患者死亡及发生心脑血管事件情况.结果 cTnT与糖尿病、心脑血管病史、hs-CRP、左心室重量指数(LVMI)呈正相关,与eGFR、左室射血分数呈负相关.生存分析显示cTnT≥0.1 μg/L组初发心脑血管事件、心脑血管事件死亡率及全因死亡率明显升高；COX比例风险回归模型分析示cTnT可预测初发心脑血管事件、心脑血管事件死亡率及全因死亡率,并独立于hs-CRP、eGFR、LVMI、左室射血分数、透析时问因素之外.结论 cTnT为腹膜透析患者初发心脑血管事件、心脑血管病死亡事件及全因死亡事件的独立预测因子.
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