125 I粒子植入联合汉防己甲素治疗局部晚期非小细胞肺癌患者的疗效及安全性观察

摘要

Objective To investigate the efficacy and side-effect of tetrandrine (Tet) combined with 125I seed implan-tation in treatment of locally advanced none-small-cell lung cancer ( NSCLC) .Methods Seventy-six patients with clinical stage Ⅲa-Ⅲb NSCLC were randomly divided into two groups: the observation group and the control group , 38 in each group.All patients were treated with 125 I seed implantation guided by CT .The prescribed dose was 110 Gy.Patients in the observation group were treated with Tet 40mg 3 times per day for 3 months since 125 I seed implantation.The efficacy and toxicity of the two groups were compared .Results All 76 patients completed the seed implantation successfully .D100 was (112.4 ±12.3)Gy, D90 was (148.7 ±22.5)Gy and mean dose was (238.9 ±11.6)Gy.With the follow-up of 21 month, the total response rates of the observation group and the control group were 86 .8%and 65 .8%, 1-year survival rates were 84.2%and 63.2%, and the median survival time were 26 and 18 months respectively (all P<0.05).The major compli-cations were pneumothorax and blood sputum .Eight patients in the control group suffered 1 degree late radioactive pulmo-nary damage and none in the observation group .Conclusion Tet combined with 125 I seed implantation for locally advanced NSCLC shows good short-term effect, high local control rate, high survival rate, less complications and no obvious adverse reactions , which is worthy of clinical application .%目的:探讨放射性125 I粒子联合汉防己甲素( Tet)治疗局部晚期非小细胞肺癌( NSCLC)的疗效及安全性。方法将76例Ⅲa~Ⅲb期NSCLC患者随机分为两组各38例。两组均在CT引导下将125 I粒子植入靶区,放射处方剂量为110 Gy。观察组在植入125 I粒子当天口服Tet,连服3个月。比较两组的疗效和毒性反应。结果76例患者均顺利完成治疗。 D100(112.4±12.3)Gy,D90(148.7±22.5)Gy,平均剂量(238.9±11.6)Gy。中位随访时间为21个月,观察组和对照组治疗6个月时的总有效率分别为86.8%、65.8%,1年生存率分别为84.2%、63.2%,中位生存时间分别为26、18个月(P均<0.05)。125I粒子植入的主要并发症为气胸及咯血,对照组出现1级晚期放射性肺损伤8例,观察组未出现晚期放射性肺损伤。结论125 I粒子联合Tet治疗局部晚期NSCLC近期疗效好、局部控制率高、患者生存率高、并发症少、无明显不良反应,值得临床应用。

著录项

相似文献

  • 中文文献
  • 外文文献
  • 专利
获取原文

联系方式:18141920177 (微信同号)

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号