目的：探讨术前中性粒细胞与淋巴细胞比值（ NLR）对甲状腺乳头状癌（ PTC）患者术后无复发生存的预测价值。方法1999年1～12月于北京协和医学院中国医学科学院肿瘤医院经手术初治的PTC患者135例，术后随访至2014年12月，记录其无复发生存情况。回顾性分析患者的临床资料，计算术前NLR，分析其预测PTC患者术后无复发生存的价值。结果术后随访时间6～180个月，中位随访时间为166个月。135例患者中，无复发生存101例。患者外周静脉血NLR为1．20～4．25，NLR＝2．93时约登指数最大，取NLR＝3作为评价分界点。多因素分析显示，TNM分期、NLR是PTC患者术后无复发生存的独立预测因素，P均＜0．05。结论术前NLR对PTC患者术后无复发生存具有预测价值，NLR≥3提示PTC患者预后较差。%Objective To investigate the predictive value of preoperative neutrophil-lymphocyte ratio ( NLR) on re-currence-free survival in patients with papillary thyroid carcinoma ( PTC) .Methods A retrospective study was performed to analyze the clinical data of 135 cases of PTC patients who accepted surgery treatment firstly in Cancer Hospital Chinese Academy of Medical Sciences , from Jan.1999 to Dec.1999.The postoperative follow-up was performed to record the recur-rence-free survival situation until December 2014.A retrospective analysis was used in these cases to calculate the preoper-ative NLR and to study its predicting value .Results The follow-up duration ranged from 6-180 months ( mean 166 months).There were 101 cases of recurrence-free survival in these 135 cases.The peripheral venous blood NLR of the pa-tients was 1.20-4.25.When NLR=2.93, it had the biggest Youden′s index, so we chose NLR =3 as the cut-off point. Multivariate analysis showed that TNM staging and NLR were the independent risk factors for postoperative recurrence -free survival in PTC patients (all P<0.05).Conclusions Preoperative NLR has the predictive value on recurrence-free sur-vival in PTC patients .Preoperative NLR≥3 predicts poorer prognosis of PTC patients .
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