含金刚烷胺的杯［4］芳烃衍生物的合成及抗菌活性研究

摘要

对叔丁基杯[4]芳烃与对甲苯磺酸酯基乙氧基对苯甲醛反应生成对叔丁基杯[4]芳烃-1，3-二醛基衍生物1，对叔丁基杯[4]芳烃-1，3-二醛基衍生物1与金刚烷胺进行分子间缩合反应得到含金刚烷基的新型杯[4]芳烃衍生物，并利用1 H NMR，13 C NMR，MS和元素分析对目标化合物的结构进行了表征。初步的抗菌试验表明，该化合物表现出较好的抑菌活性。%p-Tert-butylcalix[4]arene reacted with p-toluene sulfonic acid esteryl ethoxy-p-benzaldehyde to give 1,3-bis[2-(p-formylphenoxy)ethyloxy]-p-tert-butylcalix[4]arene 1. Reacting 1,3 -bis[2 -(p-formylphenoxy) ethyloxy]-p-tert-butylcalix[4]arene 1 with adamantanamine by intermolecular condensation,a novel biscalix[4]arene derivative containing adamantanamine unit 2 was prepared in high yield. The structure of new compound was characterized by elemental analyses,1 H NMR,13 C NMR and ESI-MS spectra.