脂氧素受体激动剂BML-111对野百合碱诱导肺动脉高压大鼠肺动脉压力及机制的研究

摘要

Objective :To observe the the effect of BML‐111 on pulmonary arterial hypertension induced by monocrotaline and potential mechanisms .Methods :24SD rats randomly divided into three groups :C group ,PH group and B group ,Both PH group and B group processed subcutaneous injection of 50ug /g monocrotaline while C group received same volume of saline ,B group performed intraperitoneal injection of BML‐111 1mg ・ kg‐1 ・ d‐1 from the day when monocrotaline was injected .The observation :MPAP ,RVSP ,RV /(LV + S) ,the concentration of en‐dotheline(ET ) and tumor necrosis factor α(TNFα) in the plasma .Results :the PH group and B group had higher level of MPAP ,RVSP ,RV /(LV + S) ,the plasma concentration of ET and TNFαcompared with C group(P < 0 . 05) ,B group caused lower increase of MPAP , RVSP , RV/(LV + S ) , the plasma concentration of ET and TNFαcompared with PH group(P < 0 .05) .Conclusion :BML‐111 can ameliorate pulmonary arterial hypertension , part of the reason may be attribute to the reduction the inflammation and decreasing the pulmonary arterial remode‐ling .%目的：观察脂氧素受体激动剂 BML‐111对野百合碱（MCT ）诱导肺动脉高压大鼠肺动脉压力的作用。方法：将 SD 大鼠24只随机分为 C 组、PH 组、B 组三组，PH 组和 B 组大鼠行皮下注射野百合碱50μg／g ，C 组注射等量生理盐水，自野百合碱注射的当天起，B 组每天腹腔注射1mg／kg ・ d BML‐111连续4周。观察指标：平均肺动脉压力（M PAP）、右心室收缩压（RVSP）、右心室（RV）／[左室（LV）＋室间隔（S）]、血浆内皮素 ET 及肿瘤坏死因子α（TNFα）。结果：PH 组、B组与 C 组相比 M PAP 、RVSP 、RV ／（LV ＋ S）、血浆 ET 及 TNFα水平高于 C 组（P＜0．05）；B 组与PH 组相比，M PAP 、RVSP 、RV ／（LV ＋ S）、血浆 ET 及 TNFα低于 PH 组（P ＜0．05）。结论：脂氧素受体激动剂 BML‐111可减轻野百合碱诱导肺动脉高压大鼠肺动脉压力，其机制可能与减轻血浆ET 及 TNFα水平，抑制肺动脉重构有关。