Objective:To investigate the clinical efficacy of knee osteoarthritis Duhuo Jisheng adjuvant treat-ment .Methods :A retrospective analysis of 86 patients with knee osteoarthritis clinical patient records and treatment ,in which the continuous intra-articular injections of sodium hyaluronate were three times as the control group ,43 cases ;the other 43 cases in the control group on the basis of Duhuo Jisheng treatment the observation group .Before and after using visual analogue scale (VAS) evaluation of joint pain cases ,the use of the former KSS score evaluable patients after treat-ment of knee function were detected before and after treatment in the synovial fluid of nitric oxide (NO) and superoxide dismutase enzyme (SOD) content ,statistical clinical efficacy and adverse reactions .Results :After treatment ,both groups VAS score and knee scores were significantly improved indicators ,then the degree of improvement in observation group than the control group significantly .Two groups of patients after treatment significantly increased SOD levels than before treatment ,NO levels were significantly decline ,and then the observation group SOD level and increased levels of NO lev-el decreased significantly better than the control group .Observation group total effective rate was 95 .3% ,significantly higher than 76 .7% .Only two minor adverse events during treatment ,follow-up treatment and did not affect the results . Conclusion :Applications Duhuojisheng adjuvant treatment of knee osteoarthritis significantly and safe .%目的:探讨独活寄生汤辅助治疗膝骨关节炎临床疗效.方法:回顾性分析86例膝骨关节炎患者临床病历及治疗情况,其中于关节腔内连续注射3次玻璃酸钠者为对照组,43例;另43例于对照组治疗基础上独活寄生汤治疗者为观察组.采用视觉模拟评分法(VAS)评价治疗前后关节疼痛情况,采用KSS评分评价患者治疗前、后膝关节功能,检测两组治疗前、后关节滑液中一氧化氮(NO)及超氧化物歧化酶(SOD)含量,统计两组临床疗效及不良反应.结果:治疗后两组患者VAS评分及膝关节各项指标评分均明显改善,然观察组改善程度较对照组显著.两组患者治疗后SOD水平较治疗前明显升高,NO水平明显下降,然观察组SOD水平升高程度及NO水平下降程度均明显优于对照组.观察组治疗总有效率95.3%,明显高于对照组76.7%.两组治疗期间仅发生轻度不良事件,均未影响后续治疗及治疗结果.结论:应用独活寄生汤辅助治疗膝骨关节炎疗效显著且安全.
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