加味疏肝汤治疗失眠症的疗效及对生活质量相关激素水平的影响

摘要

Objective:To observe the efficacy and effect on the quality of life ,the level of related hormones of Jiawei Shugan decoction in the treatment of insomnia with liver depression transforming into fire .Methods:The 167 cases were included in the study and divided into the observation group (87 cases) and control group (80 cases) .The control group was given estazolam oral treatment on the basis of routine life and psychological intervention ,and the observe group treated with Jiawei Shugant decoction on the basis of routine treatment .After 4 weeks’ treatment ,the efficacy and the change of WHOQOL‐BREF scale (including psychological ,physical ,social relations ,environmental fields) ,related hor‐mones (GH ,T3 ,COR ,T4 ,TSH ,TRH)were observed .Results :The total efficiency rate of the observation group was 89 .66% ,and that of the control group was 67 .50% ,the difference of the two groups’ efficacy was statistically significant (P<0 .05);After the treatment ,the WHOQOL‐BREF scales’ score of psychological ,physiological and social relations , environmental field of the two groups were significantly higher than those before treatment (P<0 .05) ,and the related hormones such as cor ,GH ,T3 ,T4 ,TRH and TSH were significantly lower than those before treatment (P<0 .05) .Af‐ter the treatment ,the change magnitude of WHOQOL‐BREF scales of 4 dimension and related hormone index in the ob‐servation group were greater than that of the control group ,the difference of the two group was statistically significant (P<0 .05) .Conclusion:Jiawei Shugan decoction is better than estazolam in the treatment of insomnia with liver depression transforming into fire ,and it can improve the endocrine level and the quality of life better .%目的：观察加味疏肝汤治疗肝郁化火型失眠症的疗效及对生活质量、相关激素水平的影响。方法：将纳入研究的167例肝郁化火型失眠症患者抽签分为治疗组（87例）和对照组（80例），对照组给予常规生活、心理干预以及艾司唑仑口服治疗，治疗组在常规治疗基础上给予加味疏肝汤。治疗4周观察疗效以及WHOQOL‐BREF量表、相关激素变化。结果：治疗组总有效率89．66％，对照组总有效率67．50％，两组疗效比较差异均有统计学意义（ P＜0．05）；治疗后，两组在WHOQOL‐BREF量表心理领域、生理领域、社会关系领域、环境领域4个维度得分均较本组治疗前明显上升（P＜0．05）；而相关激素COR、GH、T3、T4、TRH、TSH均较本组治疗前明显下降（P＜0．05），且治疗组治疗后WHOQOL‐BREF量表4个维度得分、相关激素指标变化幅度均大于对照组，两组比较均差异有统计学意义（P＜0．05）。结论：加味疏肝汤治疗肝郁化火型失眠症疗效优于艾司唑仑，且能更好的改善患者内分泌水平及生活质量。