不同粒径青香蕉粉的粉体特性

摘要

Green banana powder with different particle sizes were taken as the research object.The powder characteristics were analyzed,such as the fillibity,repose angle and slip angle.The effect of different particle sizes of green banana powder on tablets by direct compression method was investigated.The results showed that the size distribution of 90.07％ green banana powder ranged from 140 to 220 mesh.When mesh number of the powder increased,the tap density and bulk density reduced,the repose angle and compressibility increased.It reflected that fillibity and fluidity of the powder were worse.In addition,the hardness of green banana powder tablet increases with the mesh number increasing,the hardness of tablets had no significant difference (p ＞ 0.05)when mesh number of the powder was over 180 mesh.The disintegration time of tablet was shortest when it was 160 to 180 mesh.The green banana powder should not be more than 180 mesh when it was applied to tablet preparation.The conclusion provides basic data for the development of green banana tablet products.%以不同粒径青香蕉粉为研究对象,分析测定其填充性、休止角、滑角等粉体特性,并考察青香蕉粉不同粒径对直接压片法制备青香蕉粉片剂的影响.结果表明,90.07％青香蕉粉粒径分布范围为140～220目.随着目数的增加(粒径的减少),粉体的振实密度、松密度均减少,压缩度增加,休止角、滑角增大,粉体填充性变差,自由流动性减弱.此外,青香蕉粉片剂的硬度随粉体目数的增大而增加,高于180目时片剂硬度无显著差异(p＞0.05),160～180目时片剂崩解时间最短因此,在青香蕉片剂制备时,青香蕉粉碎目数不宜超过180目.该结论为青香蕉粉片剂型产品的开发提供数据基础.