高场非对称波形离子迁移谱分离电压的温度非线性误差建模与补偿

摘要

介绍了高场非对称波形离子迁移谱（ FAIMS）技术的基本原理，从理论上分析了驱散电压与分离电压间的线性关系。在确定驱散电压的作用下实验了分离电压的温度非线性特性。采用二次曲面方程建立了常温下分离电压的温度漂移误差补偿模型。在22.8～27.8℃的温度补偿范围内测试，结果表明，该温度补偿模型对分离电压的温度漂移具有理想的补偿效果。在不同温度条件下实现了分离电压对特定物质离子表征的唯一性。同时，该补偿方法也为迁移管的无恒温控制系统的设计提供了理想的解决方案，简化了迁移管的结构设计。%Introduces the basic principle of High-field Asymmetric Waveform Ion Mobility Spectrometry ( FAIMS) technology, the linear relationship between dispel voltage and disperse voltage in theory was analysed. The temperature nonlinear errors of the disperse voltage is studied experimentally under the condition of the determi-nation of the dispel voltage.The temperature drift errors compensation model of the disperse voltage is established by using the quadric surface equation.The results show that this temperature compensation model has an ideal com-pensation effect on the temperature drift of the disperse voltage in the range of 22.8~27.8℃, and can achieve the unique characteristics of the specific material ion under different temperature conditions.Besides, this compensa-tion method also provides an ideal solution for the design of no constant temperature control system, which reduces the design of the structure of the drift tube.