Objective : To explore the characteristics of imaging and clinicopathology of ganglioglioma (GG) so as to improve the understanding and diagnosis of the disease. Methods: The clinical presentation, imaging and histopathologic charateristics of GG were reviewed and two cases of GG in our hospital proved by histopathology and immunohistochemistry post-operatively were analyzed retrospeectively. Results : The two cases of our hospital suffered from headache as the main symptom,it was located in the ventricle system in one case and in the occipital lobe in the other. The two cases showed different imaging characteristics from each other. There was coexistence of dysplastic neuron and neoplastic glial cells with positive immunohistological staining for all three items of NSF, NeuN and GFAP. Conclusion : The imaging characteristics and clinical presentations of GG are varied in different locations. The final diagnosis should be made by pathology and immunohistochemistry.%目的:探讨脑神经节细胞胶质瘤(GG)的影像学表现及临床病理特点,提高对该病的认识.方法:复习文献并回顾性分析两例经手术病理证实的脑GG的临床、影像学表现及病理特征.结果:两例脑GG临床以头痛为主要症状,1例发生于脑室系统,1例位于枕叶;影像学上形态、密度(信号)、强化方式各异;病理学表现为发育不良的神经元与新生的胶质细胞共存;免疫组化染色NSF(+)、NeuN(+)、GFAP(+).结论:不同部位脑GG的临床及影像学表现各异,最终确诊需依靠病理学检查.
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