脑内铁沉积性神经变性病的MRI表现(附3例报告及文献复习)

摘要

目的:总结分析脑内铁沉积性神经变性病(NBIA)的MRI表现.方法:回顾性分析3例NBIA患者的MRI表现,3例均行颅脑常规MRI检查,其中2例加行磁敏感加权成像(SWI)扫描.结果:3例患者在T2WI扫描序列上均示双侧苍白球较低信号,边界较清,在低信号的内部对称出现斑点状高信号,即"虎眼征".SWI幅度图可见双侧苍白球呈极低信号,SWI相位图上"虎眼征"更加明显.结论:T2WI苍白球区域出现"虎眼征"是NBIA的特异性征象,SWI幅度图能更清晰地显示这一征象,SWI相位图能定量测量基底节区的铁沉积.%Objective:To analyse the MRI findings of neurodegeneration with cerebral iron accumulation (NCIA) for the improvement of understanding of this disease. Methods:3 cases with clinically diagnosed NCIA were enrolled in this study. All of them underwent conventional MRI of brain,SWI were performed simultaneously in two cases. Both of the con ventional MRI and SWI findings were retrospectively analyzed. Results:All cases showed hypo intensity in bilateral globus pallidus on T2WI,with clear margin and punctate calcifications inside,known as the "tiger eye" sign. Extreme hypointensity of globus pallidus was demonstrated on SWI images,the "tiger eye" sign was more obvious on SWI phase images. Conclusion: The "tiger eye" sign in globus pallidus on T2 weighted image is the characteristic feature of NCIA, which could be demonstrated more clearly on SWI,also quantitative measurement of iron deposition within basal ganglia area could be ob tained on SWI phase images.