儿童慢性肉芽肿病的 MSCT 表现及特征

摘要

Objectire:To investigate the MSCT features of chronic granulomatous disease involving thoracic and ab-dominal organs in children.Methods:The chest and abdomen CT images of 20 children with CGD diagnosed by clinical and laboratory examination or gene test were analyzed retrospectively.Results:The main manifestations on chest CT:nodules and patchy consolidation scattered in bilateral lungs in 15 cases,focal emphysema due to incomplete obstruction of bronchus in 13 cases,pleural effusion or empyema in 6 cases,ground-glass opacity in 5 cases,nodule with cavity in 4 cases,interlobu-lar septal thickening in 3 cases,hilar and axillary lymphadenectasis combined with calcification in 2 cases.The main abdomi-nal CT findings:solitary or multiple hepatic abscesses in 3 cases,hepatosplenomegaly in 12 cases,and incomplete small bowel obstruction in 1 case.Conclusion:The clinical manifestation of CGD was nonspecific,MSCT can provide important in-formation about the extent of CGD and the nature of pathogenic microorganism for clinical treatment.%目的：探讨儿童慢性肉芽肿病（CGD）累及胸腹部实质脏器的 MSCT 特征性表现。方法：回顾性分析20例CGD 患儿的胸、腹部 CT 图像资料，全部病例均经临床及实验室检查或基因检测综合诊断为 CGD。结果：胸部 CT 表现：双肺散在结节及斑片状实变影15例，支气管不全阻塞引起的局限性肺气肿13例，胸腔积液、脓胸6例，磨玻璃样密度影5例，结节伴空洞4例，小叶间隔增厚3例，肺门、腋下淋巴结肿大伴钙化2例。腹部 CT 表现：肝脏单发或多发脓肿3例，肝脾肿大12例，小肠不全梗阻1例。结论：儿童 CGD 的临床表现缺乏特异性，CT 检查在明确病变累及范围及提示病原学信息等方面具有重要参考价值。