假性甲状旁腺功能低下的临床影像诊断（附8例报告）

摘要

目的：探讨假性甲状旁腺功能低下（PHP）的临床及影像学特点，提高其影像诊断水平。方法：搜集8例经临床诊断的 PHP 患者的病例资料，对其临床表现、相关实验室及影像学检查资料进行回顾性分析。结果：所有患者甲状旁腺激素升高，低血钙及高血磷；7例发现脑内对称性钙化，4例表现为典型的 Albright 遗传性骨营养不良症（AHO），2例在X 线片上出现皮下钙化结节，1例第Ⅳ掌骨粗短。PHP 的主要 CT 表现为脑内对称性多发钙化，钙化灶于 T1 WI 和 T2 WI上呈稍高信号或等信号。结论：假性甲状旁腺功能低下患者有较特殊的临床表现，其影像学表现也有一定的特征性，CT扫描是诊断本病的有价值的影像学检查方法。%Objective:To study the clinical and imaging features of pseudohypoparathyroidism (PHP).Methods:Eight cases with PHP in our hospital were enrolled in this study.A retrospective analysis was performed based on image findings and clinical information,and relevant literatures were reviewed subsequently.Results:Hypocalcaemia,hyperphosphatemia and increased Parathyroid hormone were detected in all cases.4 patients presented Albright's hereditary osteodystrophy (AHO)characteristic,shortening of the 4th metacarpals was detected in X-ray radiograph from 1 case.The symmetrical calcification in the brain was found in 7 cases,MRI from 5 cases demonstrated that the calcification presented isointensity or slightly high signal on T1 WI and T2 WI.Calcified nodules under skin were demonstrated in 2 cases.Conclusion:Pseudohypo-parathyroidism has some specific clinical and imaging features.CT is an useful imaging modality in the diagnosis of pseu-dohypoparathyroidism.