3．0T MRI评价扩张型心肌病患者左心结构及功能的关系

摘要

Objective:To assess the correlation between the morphologic and functional parameters of left heart using cardiac magnetic resonance imaging (MRI)and its application on dilated cardiomyopathy (DCM).Methods:Forty-five pa-tients with DCM and 30 normal subjects underwent cardiac MRI.The volumes,dimensions and sphericity of the left ventri-cle and atrium in end systolic and end diastolic phase,and ejection fraction were measured.Results:Except that the ejection fraction of DCM were significantly lower than controls,the other parameters of left ventricle and left atrium were signifi-cantly higher than control subjects (P<0.05).There were good correlation between morphologic and functional parameters of left heart,and the parameters might predict DCM (area under receiver operating characteristic curve ROC= 0.850~1.000,P<0.05).Sensitivity and specificity of 100% were achieved for differentiating DCM and controls by using the ejec-tion fraction′s cutoff value of 33.1%.Conclusion:MRI can evaluate the morphological and functional changes of DCM com-pared with the controls,which can be an indicator for diagnosing DCM.%目的：利用3．0 T磁共振成像技术（MRI）评价扩张型心肌病（DCM）患者的左心结构、功能特征及其对DCM的诊断价值。方法：对45例DCM 患者及30例健康者对照进行 MRI检查，测得左心房及左心室的收缩末期容积、舒张末期容积、收缩末期内径及舒张末期内径，左心室收缩末期及舒张末期球形指数。结果：DCM患者左心室射血分数小于健康对照，其余所有左心结构指标及功能参数都大于健康对照（P＜0．05）；左心结构与功能参数相关性好，且所有参数诊断DCM的受试者工作特征曲线（ROC）下面积在0．850～1．000之间，当射血分数阈值取33．1％时，敏感度和特异度可达100％。结论：MRI可评价DCM患者左心结构及功能改变，对DCM有很好的诊断价值。