In Nineteenth century, German physiologist Emil du Bois-Reymond is the discoverer of action potential and rest potential by experimental works on frog neuromuscular specimens. He put forward a new theory- pre-existence theory. By studies for decades of Emil du Bois-Reymond and his students, a new era of bioelectrical exploration come. He has been known as the father of experimental electrophysiology.%德国生理学家埃米尔·杜波依斯-雷蒙德在19世纪中叶以青蛙神经肌肉标本为主要研究对象,首先发现和描述了静息电位和动作电位,提出了"先存学说".在他和他的学生数十年的努力下,人类对生物电的探索和认识进入了一个新的时代.
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