中国汉族人群肿瘤坏死因子-α(TNF-α)基因-238G/A和-308G/A多态性与强迫症的关联分析

摘要

Objective:To investigate the relationship between OCD and polymorphisms of-238G/A and-308G/A in TNF-a in Chinese mainland Han population.Methods:161 OCD patients and 325 controls were recruited in this study.The genotypic and allelic frequencies ofTNF-α polymorphism at positions-238G/A (rs361525) and-308G/A (rs1800629) were between OCD group and control group compared by PCR-RFLP.Results:No significant difference of-308 G/A allelic,-238 G/A genotypic and allelic frequencies in TNF-a was observed between OCD and control individuals in Chinese mainland Han population while there was significant difference in -308 G/A genotypic frequencies.There was a trend for an association in the genotypic frequencies of-308 G/A of females between OCD patients and controls.Conclusion:TNF-α 308G/A polymorphism may affect the development of OCD in Chinese mainland Han population.%目的:探讨在中国汉族人群中强迫症与TNF-a基因-238G/A和-308G/A多态性之间的关联.方法:我们的研究所招募的161例强迫症患者和325.名健康对照中,应用PCR-RFLP比较了OCD组和对照组之间的TNF-α基因在-238G/A(rs361525)和-308G/A(rs1800629)位点的基因型和等位基因频率多态性.结果:在中国大陆汉族人群TNF-α基因的OCD组与对照组之间-308 G/A等位基因频率及-238G/A的基因型频率和等位基因频率无显着差异,而-308G/A基因型频率有显著不同.在-308G/A位点,女性强迫症患者和对照组之间的基因型频率关联分析有增高的趋势.结论:我们的研究结果表明,肿瘤坏死因子-α在-308G/A点位多态性可能会影响在中国大陆汉族人群强迫症的发展.