纺织基小口径人工血管材料的体外水渗透性研究

摘要

Water permeability of an artificial vascular graft is a key indicator for evaluating the water leakage through the wall and judging whether a vascular graft should be pre - clotted before implantation. In the present study, two kinds of woven vascular grafts were prepared, and their water,simulated plasma and anticoagulant whole blood permeability were tested at different pressures. The results showed that the vascular graft with a lower porosity had a lower permeability. The permeability decreased over time and increased with the rise of the testing pressure. Under the same testing condition, the water permeability was the highest while the anticoagulant whole blood permeability was the lowest for the same kind of vascular grafts. The ratio of the simulated plasma permeability to the water permeability was approximately equal to the ratio of the viscosities of water to simulated plasma. Moreover, an approximately linear relationship could be found between any two of them.%人工血管的水渗透性是评价其植入人体之前是否需要预凝的关键指标之一.该文制备了两种孔隙率的纺织基人工血管材料.在不同压强下, 分别测量了整体水渗透性、模拟血浆渗透性及抗凝全血渗透性.结果表明, 随着测试时间的延长, 渗透性逐渐减小.随着压强的增大, 渗透性增大.孔隙率较小的试样, 渗透性较小.同种试样在相同测试条件下, 水渗透性最大, 模拟血浆渗透性次之, 抗凝全血渗透性最小.水渗透性与模拟血浆渗透性的比值近似等于模拟血浆和水的粘滞系数之比.水渗透性与抗凝全血渗透性之间、模拟血浆渗透性与抗凝全血渗透性之间, 均存在一定线性关系.