负载型贵金属催化剂在药物合成中的应用

摘要

负载型贵金属催化剂以其良好的加氢活性和选择性在化工和药物合成中都有着广泛的应用.介绍了负载型铂催化剂、负载型铑催化剂、负载型钌催化剂和负载型钯催化剂在药物合成中的氢甲酰化、氢硅烷化、烯烃异构化、氢解、转移加氢、偶联反应中的实例及应用研究进展.%Supported precious metal catalysts with high activity and high selectivity have been widely used in the drug synthesis as well as the fine chemical industry. The application of the catalysts in drug synthetic reactions including hydroformylation, hydrosilylation, isomerization, hydrogenolysis, transfer hydrogen-ation and coupling were introduced. The latest research and development were also summarized.