Objective To study the effect of irbesartan combined with atorvastatin on endothelial and serum cystatin C of elderly patients with early diabetic nephropathy. Methods Eighty-five elderly patients with early ne-phropathy of type 2 diabetes in Endocrinology Department of our hospital from January 2014 to December 2014 were selected using simple random sampling method,and were randomly divided into control group (n=43)and observation group (n=42). Patients in control group accepted routine treatment,and patients in observation group received irbesar-tan combined with atorvastatin. After six months of treatment,the ET and cystatin C were recorded and compared be-fore and at 1 month and 6 months after treatment. Results After treatment,the levels of blood pressure and Fib in ob-servation group decreased significantly,and there were significant differences between the two groups at 1 month and 6 months after treatment (P<0. 05,P<0. 01). Conclusion Irbesartan combined with atorvastatin can effectively reduce the level of endothelin and serum cystatin C of elderly patients with early diabetic nephropathy,and it can delay and re-lieve the occurrence and development of DN.%目的：探讨厄贝沙坦和阿托伐他汀联合治疗对老年早期糖尿病肾病患者内皮素( ET)和血清胱抑素C ( CysC)的影响。方法采取简单随机抽样法选取我院内分泌科2014年1-12月85例老年2型糖尿病早期肾病患者作为研究对象,随机分为2组。对照组43例,采取常规治疗；观察组42例,在常规治疗的基础上采取厄贝沙坦+阿托伐他汀联合治疗。入组干预6个月后,分别记录并比较治疗前及治疗1、6个月后各组患者的ET和胱抑素C等。结果治疗后,观察组患者的血压、纤维蛋白原(Fib)水平降低(P<0．05),治疗1、6个月后,两组比较差异有统计学意义(P<0．05,P<0．01)。结论厄贝沙坦和阿托伐他汀联合治疗,可以有效降低老年早期糖尿病肾病患者的ET、CysC水平,延缓、减轻 DN的发生和发展。
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