水飞蓟素和维生素E对维持性血液透析患者氧化应激、炎症反应及血红蛋白的影响

摘要

Objective To evaluate the effects of silymarin and/or vitamin E supplementation on oxidative stress ( OS) ,inflammation and hemoglobin levels in patients with maintenance hemodialysis. Methods A total of 80 patients with maintenance hemodialysis were randomized into four groups: silymarin group received silymarin 140 mg 3 times daily; Vitamin E group received vitamin E 400 mg once daily; Combination group received silymarin 140 mg 3 times daily and vitamin E 400 mg once daily;Control group received placebo. Samples were obtained at baseline and at the end of 4 weeks for measurement of malondialdehyde ( MDA) ,C reactive protein ( CRP) ,erythrocyte sedimenta-tion rate ( ESR) ,and hemoglobin ( HGB) . Results Silymarin group and combination group showed a remarkable re-duction in the MDA,CRP and ESR levels,and demonstrated a pronounced increase in HGB levels compared with con-trol group after treatment for 4 weeks (P<0. 05). Conclusion Silymarin and/or vitamin E supplementation leads to relief in OS and inflammation,and increases HGB levels in hemodialysis patients.%目的：探讨水飞蓟素和维生素E对维持性血液透析( MHD)患者氧化应激、炎症反应及血红蛋白的影响。方法选择80例维持性血液透析的患者,随机分为水飞蓟素组、维生素E组、联合组和对照组。水飞蓟素组口服水飞蓟素140 mg,3次/d；维生素E组口服维生素E软胶囊400 mg,1次/d；联合用药组口服水飞蓟素140 mg,3次/d,维生素E胶囊400 mg,1次/d；对照组予以安慰剂治疗。治疗前及治疗4周后,采血检测血清丙二醛(MDA)、C反应蛋白(CRP)、红细胞沉降率(ESR)及血红蛋白(HGB)水平。结果与对照组比较,治疗4周后,水飞蓟素组和联合组血清MDA、CRP和ESR水平明显降低,HGB水平明显上升(P<0．05)。结论水飞蓟素或水飞蓟素联合维生素E可以减轻MHD患者体内氧化应激及炎症反应水平,提高血红蛋白浓度。