利格列汀联合银杏叶提取物对早期二甲双胍单药治疗不佳的2型糖尿病患者肺功能的影响

摘要

目的 观察利格列汀联合银杏叶提取物对早期二甲双胍单药治疗不佳的2型糖尿病(T2DM)患者肺功能的影响,并评估其有效性与安全性.方法 收集早期(不合并微血管病变)经二甲双胍单药治疗效果不佳的T2DM患者,将其随机分为干预组(44例)和对照组(42例),并选择40例健康人作对照.对照组患者给予二甲双胍降糖、羟苯磺酸钙胶囊改善循环、甲钴胺片营养神经等治疗,干预组给予二甲双胍+利格列汀降糖、羟苯磺酸钙胶囊+银杏叶提取物片改善循环、甲钴胺片营养神经.治疗前记录三组观察对象的血糖及肺功能等.T2DM患者连续治疗24周后,记录空腹血糖(FBG)、餐后 2 h血糖(2hPG)、体重指数(BMI)与肺功能的变化情况,观察治疗过程中的不良反应.结果 治疗前,T2DM患者的FBG、PBG、BMI均高于健康人(P<0.05),肺功能各项指标低于健康人(P<0.05);治疗后,T2DM患者的FBG、PBG均降低(P<0.01),且两组FBG、PBG、BMI比较差异无统计学意义(P>0.05);治疗后,两组患者的肺功能均改善(P<0.01),且干预组优于对照组(P<0.05).治疗过程中两组均未发生严重不良反应(AEs),仅出现轻度胃肠道反应(恶心不伴呕吐)与皮肤瘙痒感,且两组不良反应发生率比较差异无统计学意义(P>0.05).结论 T2DM患者早期即出现肺功能低下,控制血糖的同时加用银杏叶提取物可改善患者的肺功能,方法安全可靠,且对体重无影响.%Objective To observe the effect of linagliptin combined with ginkgo biloba extract (GBE) on pulmonary function in T2DM patients inadequately controlled by metformin monotherapy during early period and evaluate the safety and validity.Methods Totally 84 patients with early period of T2DM (without microangiopathy) who were inadequately controlled by metformin monotherapy were randomly divided into intervention group (n=44) and control group (n=42),then 40 healthy people were selected as the controls.Patients in control group were given metformin to control the glucose,cacium hydroxybenzosulfonate to regulate microcirculation,and mecobalamin to nourish nerve.Patients in intervention group were given linagliptin+metformin to control the glucose,cacium hydroxybenzosulfonate+ginkgo biloba extract to regulate microcirculation,and mecobalamin to nourish nerve.All the patients were treated for 24 weeks.The changes of fasting plasma glucose (FBG),2-hour postprandial blood glucose (2hPG),body mass index (BMI) and pulmonary function were observed before and after treatment.Results Before treatment,the levels of FBG,2hPG and BMI in the T2DM patients were higher than those of healthy controls (P<0.05),and the indexes of pulmonary function were lower (P<0.05).After treatment,the FBG and 2hPG of T2DM patients decreased (P<0.01),and there was no significant difference in FBG,2hPG and BMI between the two T2DM groups (P>0.05);the pulmonary function was improved (P<0.01) in the two groups,which was better in intervention group (P<0.05).The AEs mainly included gastrointestinal events (nausea without vomiting),skin-related AEs (mostly because of pruritic events),and there was no significant difference in the incidences of AEs between the two T2DM groups (P>0.05).Conclusion The T2DM patients have worse pulmonary function than healthy people during the early period.Ginkgo biloba extract combined blood sugar control can improve the pulmonary function without influence on weight,which is safe and reliable.