脑卒中后疲劳患者血清白介素－1β水平变化及早期护理干预效果研究

摘要

目的：探讨脑卒中后疲劳（ PSF）患者血清白介素－1β（ IL－1β）水平变化及早期护理干预效果，为PSF的防治提供参考。方法选取2013年12月—2014年6月我院收治的缺血性脑卒中患者105例，随机分为对照组52例和干预组53例。对照组患者实施常规治疗和护理，干预组患者在对照组基础上实施早期护理干预。干预2周后，采用疲劳严重度量表（ FSS）判断所有患者是否发生PSF，并检测其血糖、糖化血红蛋白（ HbA1c ）、 IL－1β、 HDL－C、 LDL－C、 TC及TG。结果干预组患者FSS总分为（2.9±1.5）分，低于对照组的（3.8±1.7）分（ P＜0.05）。干预组13例患者发生PSF （干预－PSF组），40例患者未发生PSF （干预－非PSF组）；对照组23例患者发生PSF （对照－PSF组），29例患者未发生PSF （对照－PSF组）。干预－PSF组血糖、 HbA1c、 IL－1β、 HDL－C高于对照－PSF组和干预－非PSF组，对照－PSF组血糖、 HbA1c、 IL－1β、 HDL－C高于对照－非PSF组（ P＜0.05）。结论PSF患者血清IL－1β水平明显升高， IL－1β在PSF的发生和发展过程中发挥着重要作用；早期护理干预有助于减少PSF的发生，延缓PSF的发展。%Objective To investigate the changes of serum interleukin -1β( IL-1β) level in patients with post stroke fatigue ( PSF) and effect of early nursing intervention , to provide references for prevention and treatment .Methods From December 2013 to June 2014, 105 patients with ischemic stroke were selected in our hospital , and they were randomly di-vided into control group (n=52) and intervention group (n=53) .Control group given routine treatment and nursing , while intervention group given early nursing intervention based on routine treatment and nursing.After 2 weeks of intervention , fatigue severity scale (FSS) was used to judge PSF, and blood glucose, HbA1c, IL-1β, HDL-C, LDL-C, TC, TG were detec-ted.Results The total score of FSS of intervention group was (2.9 ±1.5), was lower than that of control group of (3.8 ± 1.7) (P<0.05) .In the intervention group, 13 cases occurred PSF (intervention-PSF group), 40 cases did not (interven-tion-non PSF group ); in the control group , 13 cases occurred PSF ( control-PSF group ) , 29 cases did not ( control -non PSF group) .Blood glucose, HbA1c, IL-1β, HDL-C of intervention -PSF group were higher than those of control -PSF group and intervention-non PSF group , and those of control -PSF group were higher than those of control -non PSF group ( P<0.05).Conclusion Serum IL-1βlevel is higher in patients with PSF , which plays a important role in the onset and devel-opment of PSF , and early nursing intervention is helpful to reduce and postpone PSF .