Objective To analyze the changes and clinical significance of peripheral blood monocytes,neutrophils and PLT of patients with lower extremity deep venous thrombosis (LEDVT).Methods From February 2015 to June 2016 in the Department of Extremities Microsurgery,the 463rd Hospital of Chinese People's Liberation Army,a total of 100 inpatients with LEDVT were selected as case group,and they were divided into A group (with chronic stage,n =34),B group (with subacute stage,n =31) and C group (with acute stage,n =35) according to disease stage;meanwhile a total of 30 healthy adults admitted to this hospital for physical examination were selected as control group.Peripheral blood monocytes,neutrophils and PLT before treatment,after 7 days and 14 days of treatment were compared among the four groups.Results (1) Before treatment and after 7 days of treatment,peripheral blood monocytes of A group,B group and C group was statistically significantly higher than that of control group,respectively,peripheral blood monocytes of B group and C group was statistically significantly higher than that of A group,respectively,peripheral blood monocytes of C group was statistically significantly higher than that of B group (P ＜ 0.05);while no statistically significant differences of peripheral blood monocytes was found among the four groups after 14 days of treatment (P ＞ 0.05).(2) Before treatment and after 7 days of treatment,peripheral blood neutrophils of A group,B group and C group was statistically significantly higher than that of control group,respectively,peripheral blood neutrophils of B group and C group was statistically significantly higher than that of A group,respectively,peripheral blood neutrophils of C group was statistically significantly higher than that of B group (P ＜ 0.05);while no statistically significant differences of peripheral blood neutrophils was found among the four groups after 14 days of treatment (P ＞ 0.05).(3) Before treatment and after 7 days of treatment,peripheral blood PLT of A group,B group and C group was statistically significantly higher than that of control group,respectively,peripheral blood PLT of B group and C group was statistically significantly higher than that of A group,respectively,peripheral blood PLT of C group was statistically significantly higher than that of B group (P ＜ 0.05);after 14 days of treatment,peripheral blood PLT of C group was statistically significantly higher than that of control group,A group and B group,respectively (P ＜ 0.05),while no statistically significant differences of peripheral blood PLT was found among control group,A group and B group (P ＞ 0.05).Conclusion Peripheral blood monocytes,neutrophils and PLT are correlated with disease progression in patients with LEDVT,can be reference for staging of LEDVT.%目的 分析下肢深静脉血栓形成患者外周血单核细胞、中性粒细胞、血小板计数变化及其临床意义.方法 选取2015年2月-2016年6在解放军第四六三医院手足显微外科住院治疗的下肢深静脉血栓形成患者100例作为病例组,根据疾病分期分为慢性期组34例、亚急性期组31例及急性期组35例;另选取同期在本院体检健康者30例作为对照组.比较4组受试者治疗前及治疗后7、14 d外周血单核细胞、中性粒细胞、血小板计数.结果 (1)治疗前和治疗后7d慢性期组、亚急性期组及急性期组受试者外周血单核细胞计数高于对照组,亚急性期组、急性期组患者外周血单核细胞计数高于慢性期组,急性期组患者外周血单核细胞计数高于亚急性期组(P＜0.05);治疗后14 d4组受试者外周血单核细胞计数比较,差异无统计学意义(P＞0.05).(2)治疗前及治疗后7d慢性期组、亚急性期组及急性期组患者外周血中性粒细胞计数高于对照组,亚急性期组、急性期组患者外周血中性粒细胞计数高于慢性期组,急性期组患者外周血中性粒细胞计数高于亚急性期组(P＜0.05);治疗后14d4组受试者外周血中性粒细胞计数比较,差异无统计学意义(P＞0.05).(3)治疗前及治疗后7d慢性期组、亚急性期组及急性期组患者外周血血小板计数高于对照组,亚急性期组、急性期组患者外周血血小板计数高于慢性期组,急性期组患者外周血血小板计数高于亚急性期组(P＜0.05);治疗后14 d急性期组患者外周血血小板计数高于对照组、慢性期组、亚急性期组(P＜0.05),而对照组、慢性期组、亚急性期组受试者外周血血小板计数比较,差异无统计学意义(P＞0.05).结论 外周血单核细胞、中性粒细胞及血小板计数与下肢深静脉血栓形成患者病情进展有关,可作为下肢深静脉血栓形成分期的参考依据.
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