中老年血脂异常人群易患糖代谢异常的研究

摘要

Objective To investigate and analyze the abnormal glucose metabolism and clinical characteristics in middle-aged and elderly individuals with dyslipidemia based on “Guidelines on Prevention and Treatment of Dyslipidemia for Chinese Adults (2007 Edit)”. Methods Totally 1136 individuals aged over 40 were included in this study. The subjects were divided into normolipidemia group, and dyslipidemia group. Frequencies of isolated impaired fasting glucose (I-IFG), isolated impaired glucose tolerance (I-IGT), impaired glucose regulation (IGR) and type 2 diabetes mellitus (T2DM) were compared and the blood glucose levels were determined. Results ① The ratio of dyslipidemia was 47. 8％. The age, systolic blood pressure( SBP), diastolic blood pressure( DBP), waist circumference( WC), waist/hip ratio(WHR), waist/height ratio(WHtR), body mass index(BMI) in dyslipidemia group were all higher than those in normolipidemia group (all P ＜ 0. 01 ). ②The frequencies of I-IFG, I-IGT, IGR and T2DM in dyslipidemia group were significantly higher than those in normolipidemia subjects (P ＜0. 05 or P ＜0. 01 ). The mixed dyslipidemia (Mix-DL) subjects had the highest incidences of IGR (31.0％), and T2DM ( 11.2％ ). ③ The levels of fasting blood glucose (FBG),2 h post prandial blood glucose (2hPG) and glycosylated hemoglobin (HbAlc) in dyslipidemia group were higher than those in normolipidemia group( P ＜ 0. 01 ). Conclusions The middle-aged and elderly individuals in dyslipidemia group have higher total body fat, regional body fat, blood pressure and frequencies of I-IFG, I-1GT, IGR and T2DM than those in normolipidemia group. The patients with Mix-DL are prone to have higher risk of abnormal glucose metabolism.%目的 依据中国成人血脂异常防治指南(2007版),调查并分析中老年血脂代谢紊乱人群糖代谢异常情况及临床特征.方法 1136例≥40岁人群纳入研究,按照血脂水平分为血脂正常组和血脂异常组,分别比较各组孤立性空腹血糖受损(I-IFG)、孤立性糖耐量异常(I-IGT)、糖调节异常(IGR)、2型糖尿病(T2DM)患病率以及血糖水平.结果①受检人群血脂异常的比例高达47.8%.血脂异常人群的年龄、收缩压(SBP)、舒张压(DBP)、腰围(WC)、腰臀比(WHR)、腰围身高比(WHtR)、体质量指数(BMI)均明显高于血脂正常组(P均＜0.01).②血脂异常人群I-IFG、I-IGT、IGR和T2DM比例显著高于血脂正常组(P＜0.05或P＜0.01).混合性血脂紊乱(Mix-DL)伴发IGR的频率高达31.0%,有11.2%患者合并T2DM.③血脂异常组空腹血糖(FBG)、餐后2 h血糖(2hPG)和糖化血红蛋白(HbA1c)均高于血脂正常组(P＜0.01).结论中老年血脂异常人群具有较高的总体脂、局部体脂和血压水平,糖代谢异常风险增高,Mix-DL患者糖调节受损更为显著.