他达那非联合十一酸睾酮治疗中老年男性勃起功能障碍伴迟发性性腺功能减退症的研究

摘要

Objective To investigate the effect of tadalafil combined with andriol on erectile dysfunction (ED) with late-onset hypogonadism (LOH). Methods Totally 45 patients were divided into two groups: study group with 23 patients were treated by tadalafil combined with andriol, and control group with 22 patients were treated with tadalafil only.The therapeutic efficacy of the two groups were compared by the score of questionnaire of 5-item version of the international index of erectile function ( ⅡEF-5 ) and a males' symptoms ( AMS ) after four weeks. Results After treatment, the scores of ⅡEF-5 were significantly increased, and the scores of AMS were remarkably decreased in study group( P ＜0. 05 );While the scores of ⅡEF-5 and AMS in study group were improved more statistically than those in control group ( P ＜0. 05 ). Conclusions Tadalafil combined with andriol in the treatment of ED with LOH has an advantage than single tadalafil in aging males.%目的 观察他达那非联合十一酸睾酮治疗中老年男性勃起功能障碍(ED)伴迟发性性腺功能减退症(LOH)患者的临床疗效.方法 将符合标准的45例患者分为2组,研究组23例,采用他达那非联合十一酸睾酮的治疗方案,对照组22例,单用他达那非治疗.4周后,应用国际勃起功能指数评分-5(IIEF-5)、老年男性症状问卷(AMS)比较2组的治疗效果.结果 2组治疗后IIEF-5评分较治疗前增加(P均<0.05),研究组AMS评分均较治疗前降低(P<0.05),研究组治疗后2项评分较对照组明显改善(P均<0.05).结论在中老年ED伴LOH患者的治疗中,联合应用他达那非和十一酸睾酮的治疗效果优于单用他达那非的效果.