老年原发性失眠的神经心理学测验与P300检测的关系及其意义

摘要

Objective To investigate the cognitive impairment and its sevority caused by primary insomnia in elderly patients. Methods Neuropsychology test(MMSE, MoCA scales) and P300 detection were used to exam 52 cases of primary insomnia and 60 cases of healthy controls. Results MoCA scale in space and executive function, attention, delayed recall scares and total scores in elderly patients were significantly decreased than those in control group. MMSE scale score also decreased, but the difference was not statistically significant. P300 showed that whether the target stimulus or non-target stimuli induced a low, flat wave. Conclusions Aging patients with primary insomnia suffer cognitive impairment. Combined detection of MoCA scales and P300 test can conduce to the diagnosis of prophase cognitive impairment.%目的 了解老年原发性失眠患者认知功能有无损害及其程度. 方法 用神经心理学检测(MMSE、MoCA量表)、P300检测52例老年原发性失眠患者及60例正常体检者. 结果老年原发性失眠患者MoCA量表中视空间与执行功能、注意、延迟回忆得分及总分较对照组显著下降,差异有统计学意义(P＜0.01).MMSE量表评分亦有下降趋势,但差异无统计学意义.P300结果显示无论是靶刺激还是非靶刺激,其诱发出的波明显低平及后移,差异有统计学意义(P＜0.01). 结论 老年原发性失眠患者存在认知功能损害,联合MoCA量表评估及P300检测有助于老年原发性失眠患者早期认知功能损害的诊断.