基层医院老年患者泌尿系假丝酵母菌感染分析

摘要

Objective To observe the status of urinary tract infection by candida among elderly patients in primary hospital,and to provide the evidence for clinical diagnosis and treatment.Methods The midstream urine fungal culture and sensitivity test results were retrospectively analyzed in elderly patients with suspected urinary tract fungal infections from January 2010 to June 2012.Results Thirty-four strains of candida were isolated from 176 samples.Twelve strains were from general ward,with the positive rate of 9.4％,and 22 strains were from ICU,with the positive rate of 44.9％ (P ＜0.01).The most common strains were candida tropicalis (41.2％),candida glabrata (26.5％) and candida albicans (16.7％).Drug sensitivity test showed that susceptibility to 5-flucytosine,fluconazole,voriconazole,amphotericin B,Itraconazole was 94.1％,76.5％,88.2％,100％,73.5％ respectively.Conclusions Patients in ICU are more susceptible to urinary tract candida infection.Candida tropicalis,candida glabrata and candida albicans are the most common strains.Common azole antifungals appear obvious resistance.%目的 了解基层医院老年患者临床泌尿系假丝酵母菌感染现状,为临床诊疗提供参考. 方法 回顾性分析2010年1月至2012年6月,内科≥70岁疑似泌尿系真菌感染患者的中段尿真菌培养结果及药敏试验结果. 结果 从176例患者中检出假丝酵母34株,其中内科普通病区12株,检出率为9.4％；内科监护病房22株,检出率为44.9％,差异有统计学意义(P＜0.01).检出菌株中热带假丝酵母菌(41.2％)最常见,其次为光滑假丝酵母菌(26.5％)和白假丝酵母菌(16.7％).药敏提示5-氟胞嘧啶、氟康唑、伏立康唑、两性霉素B、伊曲康唑的敏感性分别为94.1％、76.5％、88.2％、100％、73.5％. 结论 内科监护病房疑似泌尿系假丝酵母菌感染患者检出率高.热带假丝酵母菌、光滑假丝酵母菌和白假丝酵母菌占检出前3位.