目的 探索含有头孢哌酮舒巴坦(CFS)的抗感染治疗对感染碳青霉烯耐药鲍曼不动杆菌(CRAB)的老年医院获得性肺炎(HAP)病人的体内外抗菌效果.方法 选取63例老年HAP病人感染CRAB的临床病例,根据治疗中是否有CFS分为2组,对比分析2组间的疗效差异.同时选取临床分离的50株CRAB菌株进行包含CFS的联合药敏实验.结果 (1)采用CFS的治疗组30 d生存率是94.4%,未采用CFS的对照组30 d生存率是70.4%,2组比较差异有统计学意义(P<0.05).(2)CFS与米诺环素、左氧氟沙星或美罗培南联用时,主要表现为协同及相加作用.结论 含有CFS的药物组合对感染CRAB的老年HAP病人有很好的治疗效果.%Objective To explore the effect of cefoperazone sulbactam ( CFS ) on hospital-acquired pneumonia(HAP) in elderly patients caused by carbapenem-resistant acinetobacter baumannii ( CRAB) . Methods Sixty-three elderly cases of HAP caused by CRAB were selected, and they were divided into two groups according to whether the treatment contained CFS. 30-day survival rate of the two groups were compared. Meanwhile, 50 strains of CRAB isolated from clinical patients were used for combined drug sensitivity test. Results The 30-day survival rate of patients treated with CFS was 94. 4%, compared with 70. 4% in non CFS group ( P<0. 05 ) . CFS combined with levofloxacin, meropenem or minocycline, mainly showed synergistic and additive inhibitory effect on CRAB strains in vitro. Conclusions The antimicrobial drug combinations containing CFS has a good effect on HAP in elderly patients caused by CRAB.
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