Objective To investigate the effect of lentinan on T cell subsets, IL-2 and IL-6 in elderly patients with breast cancer receiving chemotherapy. Methods A total of 80 elderly patients with breast cancer were randomly divided into control group ( n=40) and treatment group ( n=40) . The two groups recieved treatment with chemotherapy, and the observation group was additionally given lentinan. The levels of T cell subsets, IL-2 and IL-6 of two groups were compared. Results After treatment, the levels of CD4+and CD4+/CD8+decreased significantly in control group ( P<0. 05) , while showing no significant difference in observation group ( P>0. 05) . The levels of CD4+and CD4+/CD8+in observation group were significantly higher than those in control group ( P<0. 05) . Compared with before treatment, the level of IL-2 increased significantly in observation group after treatment ( P<0. 05) and decreased significantly in control group ( P<0. 05 ) , and the level of IL-6 decreased significantly in observation group ( P<0. 05 ) and increased significantly in control group ( P<0. 05 ) . There was significant difference in levels of IL-2 and IL-6 between two groups ( P>0. 05) . The incidence of adverse reaction in observation group(50. 00%) was significantly lower than that in control group(80. 00%). Conclusions Lentinan can enhance CD4+ activity, improving the levels of IL-2 and IL-6, regulating immune function in elderly patients with breast cancer receiving chemotherapy.%目的：探讨香菇多糖对老年乳腺癌化疗病人T细胞亚群及血清白细胞介素-2（ IL-2）、白细胞介素-6（ IL-6）的影响。方法将80例于我院进行治疗的老年乳腺癌病人随机分为对照组和观察组，每组各40例。对照组病人进行化疗，观察组在对照组的基础上静脉滴注香菇多糖注射液，比较2组治疗前、后T细胞亚群（ CD4＋、CD8＋、CD4＋／CD8＋）及血清IL-2、IL-6水平的变化。结果对照组治疗后CD4＋及CD4＋／CD8＋均较治疗前显著降低，差异有统计学意义（ P＜0.05），观察组治疗前后CD4＋、CD8＋及CD4＋／CD8＋比较差异均无统计学意义（ P＞0.05），且治疗后观察组CD4＋及CD4＋／CD8＋均显著高于对照组，差异有统计学意义（ P＜0.05）；与治疗前比较，治疗后，观察组IL-2水平显著升高，对照组显著降低（ P＜0.05），观察组IL-6水平显著降低，对照组显著升高（ P＜0.05）；治疗后2组间IL-2、IL-6水平比较，差异有统计学意义（ P＜0.05）。观察组不良反应发生率为50.00％，显著低于对照组的80.00％，差异有统计学意义（ P＜0.05）。结论香菇多糖辅助乳腺癌病人化疗，能够显著提高老年化疗病人CD4＋细胞活性，改善体内IL-2、IL-6水平，调节人体免疫功能，减轻免疫抑制。
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